Research Article
Kinetic Profiles of Inflammatory Mediators in the Conjunctival Sac Fluid of Patients upon Photorefractive Keratectomy
Table 1
Cytokines and chemokines levels in conjunctival sac fluid of patients undergoing PRK.
| | Cytokines and chemokines | 1 day before PRK (pg/mL) | Follow-up after PRK | | | | 2 days (pg/mL) | 5 days (pg/mL) | 30 days (pg/mL) |
| | EGF | Epidermal growth factor | 68.7 (82.4 ± 52.3) | 13.8 (25.0 ± 38.7) | 76.7 (88.7 ± 65.6) | 80.2 (95.2 ± 58.0) | | Eotaxin | C-C motif chemokine ligand 11 | 0.0 (2.4 ± 4.8) | 0.0 (0.8 ± 2.8) | 6.4 (6.7 ± 7.0) | 8.5 (7.1 ± 5.8) | | G-CSF | Granulocyte colony-stimulating factor | 31.5 (41.3 ± 27.0) | 12.8 (15.4 ± 16.2) | 26.1 (32.9 ± 24.4) | 46.8 (52.7 ± 27.4) | | GM-CSF | Granulocyte-macrophage colony-stimulating factor | 0.7 (0.9 ± 0.7) | 0.0 (0.4 ± 0.6) | 1.1 (1.4 ± 0.8) | 1.6 (1.4 ± 0.6) | | IFN-2 | Interferon, alpha2 | 38.2 (47.0 ± 26.7) | 23.7 (27.1 ± 19.9) | 33.3 (33.7 ± 19.1) | 44.4 (46.9 ± 24.6) | | IFN- | Interferon, gamma | 2.1 (3.3 ± 4.6) | 0.0 (0.8 ± 0.9) | 2.6 (2.8 ± 1.5) | 2.7 (2.8 ± 1.2) | | IL-10 | Interleukin 10 | 1.3 (1.8 ± 1.0) | 0.8 (0.7 ± 0.7) | 1.6 (1.8 ± 1.1) | 2.2 (2.3 ± 0.9) | | IL-12(p40) | Interleukin 12 subunit p40 | 3.6 (3.3 ± 2.7) | 2.8 (2.1 ± 2.3) | 4.5 (4.1 ± 3.1) | 5.1 (5.1 ± 3.6) | | IL-12(p70) | Interleukin 12 complex | 2.5 (2.5 ± 2.1) | 0.0 (0.6 ± 1.2) | 3.4 (3.2 ± 2.3) | 3.9 (3.6 ± 2.2) | | IL-13 | Interleukin 13 | 14.3 (19.2 ± 14.1) | 3.0 (5.2 ± 8.0) | 14.6 (17.6 ± 13.3) | 26.9 (29.9 ± 17.0) | | IL-15 | Interleukin 15 | 1.3 (1.2 ± 1.1) | 0.0 (0.4 ± 0.7) | 2.1 (1.9 ± 1.4) | 2.1 (2.2 ± 1.2) | | IL-17A | Interleukin 17 | OOR< | OOR< | OOR< | OOR< | | IL-1RA | Interleukin 1 receptor antagonist | 562.0 (703.7 ± 562.5) | 95.1 (141.5 ± 152.9) | 498.0 (663.8 ± 579.5) | 895.3 (920.4 ± 550.8) | | IL-1 | Interleukin 1, alpha | 11.0 (11.2 ± 5.1) | 6.7 (8.4 ± 6.0) | 13.5 (14.8 ± 6.5) | 16.9 (19.0 ± 8.2) | | IL-1 | Interleukin 1, beta | 0.7 (0.7 ± 0.8) | 0.7 (0.8 ± 1.0) | 1.4 (1.4 ± 1.0) | 1.6 (1.9 ± 1.1) | | IL-2 | Interleukin 2 | 0.0 (0.5 ± 0.7) | 0.0 (0.2 ± 0.4) | 0.7 (0.7 ± 0.6) | 0.9 (0.9 ± 0.6) | | IL-3 | Interleukin 3 | OOR< | OOR< | OOR< | OOR< | | IL-4 | Interleukin 4 | 5.25 (16.1 ± 36.7) | 0.0 (4.7 ± 10.83) | 3.6 (8.1 ± 15.3) | 8.7 (12.1 ± 8.8) | | IL-5 | Interleukin 5 | 1.2 (2.7 ± 3.0) | 0.0 (0.4 ± 1.3) | 1.02 (1.9 ± 2.4) | 2.4 (3.4 ± 3.2) | | IL-6 | Interleukin 6 | 2.4 (3.1 ± 2.4) | 7.5 (9.9 ± 10.4) | 2.9 (4.6 ± 5.5) | 3.1 (3.5 ± 3.3) | | IL-7 | Interleukin 7 | 13.7 (16.1 ± 7.8) | 4.9 (7.1 ± 8.6) | 13.7 (16.9 ± 11.3) | 24.8 (24.6 ± 11.0) | | IL-8 | Interleukin 8 | 22.3 (29.9 ± 18.2) | 24.5 (38.8 ± 30.9) | 21.3 (38.4 ± 35.2) | 20.3 (30.2 ± 18.2) | | IP-10 | CXCL10 | 1432.0 (2026.6 ± 1896.5) | 185.0 (435.0 ± 538.8) | 2428.0 (3241.1 ± 2564.3) | 2856.5 (3303.1 ± 1751.1) | | MCP-1 | CCL2 | 34.9 (83.4 ± 103.3) | 80.0 (138.9 ± 104.1) | 150.9 (144.2 ± 130.0) | 115.9 (162.7 ± 128.5) | | MIP-1 | CCL3 | 0.0 (2.3 ± 3.5) | 0.0 (1.1 ± 2.1) | 5.2 (4.0 ± 4.3) | 5.2 (5.0 ± 4.4) | | MIP-1 | CCL4 | 3.6 (4.5 ± 2.7) | 1.3 (1.7 ± 1.8) | 6.2 (5.7 ± 3.7) | 5.6 (6.3 ± 3.2) | | TNF- | Tumor necrosis factor, alpha | 0.0 (0.3 ± 0.6) | 0.0 (0.0 ± 0.1) | 0.7 (0.9 ± 1.3) | 0.8 (0.7 ± 0.5) | | TNF- | Tumor necrosis factor, beta | 0.0 (0.4 ± 0.8) | 0.0 (0.1 ± 0.4) | 0.0 (0.6 ± 0.9) | 0.0 (0.7 ± 0.9) | | VEGF | Vascular endothelial growth factor | 29.1 (31.9 ± 17.4) | 8.7 (12.2 ± 11.7) | 29.1 (42.8 ± 50.9) | 52.6 (52.8 ± 21.8) |
|
|
Values are expressed as median (mean ± SD); OOR<: out (below) of detection range.
|
