Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation

Figure 2

Endothelial signaling pathways induced upon clustering of ICAM-1 and VCAM-1 leading to the formation of endothelial F-actin-rich apical cup structures and the dissociation of endothelial adherens junctions. Endothelial signals that are induced by specific leukocyte types are color-coded: neutrophils in green, monocytes in red, T cells in blue, and B cells in purple. In case signaling proteins are identified by studies using different leukocyte types, the background color of the protein name is adapted to the leukocyte type used. In case specific signaling is studied in the absence of leukocytes the color is black. Short stripes indicate glycosylation. Question mark indicates that GlyCAM-1, as a soluble protein, may reassociate to the endothelial membrane.