Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update

Table 1

Recently described roles for MMPs in IBD.

MMP	Role in IBD	Reference
MMP-1	Prevention of fibrosis	[145]
MMP-2	Generation of antiangiogenic factors, maintenance of epithelial barrier function, and prevention of fibrosis	[119, 135, 145]
MMP-3	Generation of endostatin	[118]
MMP-7	α-defensin activation, chemokine expression, wound healing, and generation of endostatin	[105, 106, 118]
MMP-8	Neutrophil infiltration	[18]
MMP-9	Chemokine expression, neutrophil infiltration, generation of anti-angiogenic factors, VEGF-A processing, decreased goblet cell differentiation, and prevention of fibrosis	[18, 107, 118, 119, 125, 134, 145]
MMP-10	Wound healing,	[19]
MMP-13	Activation of TNF-α and generation of endostatin	[111, 118]
MMP-20	Generation of endostatin	[118]