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Mediators of Inflammation
Volume 2015, Article ID 979526, 8 pages
http://dx.doi.org/10.1155/2015/979526
Clinical Study

Selected Inflammatory and Metabolic Markers in Psoriatic Patients Treated with Goeckerman Therapy

1Institute of Clinical Immunology and Allergology, University Hospital Hradec Kralove, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Sokolska 581, 50005 Hradec Kralove, Czech Republic
2Institute of Pathological Physiology, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Sokolska 581, 50005 Hradec Kralove, Czech Republic
3Department of Dermatology and Venereal Diseases, University Hospital Hradec Kralove, Sokolska 581, 50005 Hradec Kralove, Czech Republic
4Department of Transfusion Medicine, University Hospital Hradec Kralove, Sokolska 581, 50005 Hradec Kralove, Czech Republic
5Institute of Hygiene and Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Sokolska 581, 50005 Hradec Kralove, Czech Republic

Received 20 February 2015; Revised 11 May 2015; Accepted 31 May 2015

Academic Editor: Luca Cantarini

Copyright © 2015 Katerina Kondelkova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Psoriasis is associated with metabolic activity of adipose tissue which produces pro- and anti-inflammatory adipokines. Goeckerman therapy (GT) represents an effective treatment of psoriasis. This study evaluated variation of selected inflammatory and metabolic markers during GT and the relationships between the markers, severity of the disease (PASI score), body mass, and the basic characteristics of the therapy. The study was conducted on a group of patients and on a control group . Before GT, we found significantly elevated levels of proinflammatory CRP and leptin in psoriatic patients (compared to the controls). The therapy significantly decreased the levels of CRP and adiponectin. We found positive correlations between CRP and total duration of GT () and CRP and the time of UV exposure () and negative correlations between adiponectin and the total duration of GT () and adiponectin and the application of CCT ointment (). From our results, we can conclude that GT causes partial reduction of both proinflammatory and anti-inflammatory markers. However, the levels of proinflammatory CRP and leptin remained significantly higher in the patients than in the control group.