Genetic Investigation of Complement Pathway Genes in Type 2 Diabetic Retinopathy: An Inflammatory Perspective
Table 3
Comparison of genotype and allele frequency of C5-rs17611 in DR and DM stratified by disease severity.
SNP ID
Genotype/allele
NPDR ()
PDR ()
DM ()
NPDR versus DM
PDR versus DM
P value
Odds ratio (95% CI)
P value
Odds ratio (95% CI)
rs17611
GG
20 (14.4)
12 (7.7)
51 (18.5)
0.51
1.15 (0.75–1.78)
0.062
0.68 (0.46–1.02)
AG
73 (52.5)
73 (46.8)
124 (45.1)
0.29
0.74 (0.42–1.30)
0.002 (0.016)
0.37 (0.19–0.71)
AA
46 (33.1)
71 (45.5)
100 (36.4)
0.62
0.85 (0.46–1.59)
0.001 (0.008)
0.33 (0.17–0.67)
G
113 (40.6)
97 (31.1)
226 (41.1)
0.90
0.98 (0.73–1.32)
0.004 (0.032)
0.65 (0.48–0.87)
A
165 (59.4)
215 (68.9)
324 (58.9)
Data are the number of subjects (% of the total group). NPDR: nonproliferative diabetic retinopathy; PDR: proliferative diabetic retinopathy; DM: diabetes mellitus. value for dominant model; value for recessive model; value for codominant model.
