Genetic Investigation of Complement Pathway Genes in Type 2 Diabetic Retinopathy: An Inflammatory Perspective

Table 5

Haplotype association of C5 gene with DR and its subtypes.

Haplotype; rs17611-; rs1548782	Frequency				Association (P value) (permutation test)
	Total DR	NPDR	PDR	DM	DR versus DM	NPDR versus DM	PDR versus; DM
A-A	0.64	0.59	0.69	0.59	0.064	0.94	0.004; (0.023)
G-T	0.20	0.23	0.17	0.20	0.88	0.29	0.21
G-A	0.16	0.17	0.15	0.21	0.025; (0.11)	0.21	0.019; (0.09)

NPDR: nonproliferative diabetic retinopathy; PDR: proliferative diabetic retinopathy; DM: diabetes mellitus. association analysis results from permutation test (iterations 10,000).