Irbesartan Ameliorates Diabetic Nephropathy by Suppressing the RANKL-RANK-NF-κB Pathway in Type 2 Diabetic db/db Mice

Figure 4

Irb attenuated diabetes-induced MCP-1 expression. (a) Urinary MCP-1 was significantly increased in db/db mice and significantly reduced in db/db mice with treatment of Irb. (b) The mRNA level of MCP-1 in the kidney was increased in the db/db mice and reversed by Irb treatment significantly. The bars in panels (a) and (b) show the mean expression in arbitrary units (error bars, S.D.). compared with db/m; compared with db/db, -test.

(a)  

(b)