HIV Progression Perturbs the Balance of the Cell-Mediated and Anti-Inflammatory Adaptive and Innate Mycobacterial Immune Response

<div>HIV progression increases the immune skewing towards nonlymphocyte IL-10 and away from lymphocyte IFN-<i>γ</i>. PBMCs from HIV-TB coinfected patients were stimulated with<i> Mycobacterium bovis (M. bovis</i>) lysate to evaluate the etiology of IL-10 production. (a) Representative dot plots showing the relative contribution of cell types towards IL-10 production. Side scatter (SSA-A) and forward scatter (FSA-A), CD3, CD56, and CD14 were used to evaluate the lymphocyte or nonlymphocyte contribution of IL-10 production. (b) Spearman correlation of the mycobacteria-specific nonlymphocyte IL-10 : total lymphocyte IFN-<i>γ</i> production based on the CD4 : CD8 decline.</div>

Mediators of Inflammation

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Figure 2

Figure 2: HIV Progression Perturbs the Balance of the Cell-Mediated and Anti-Inflammatory Adaptive and Innate Mycobacterial Immune Response 