P-Selectin Targeted Dexamethasone-Loaded Lipid Nanoemulsions: A Novel Therapy to Reduce Vascular Inflammation

Figure 2

The anti-inflammatory effect of free dexamethasone (Dex) or encapsulated in nontargeted (LN-Dex) or P-selectin targeted (PLN-Dex) lipid nanoemulsions assessed by the expression of mRNA of several proinflammatory molecules in TNF-α activated EC by quantitative RT-PCR and normalized to beta-actin mRNA. Empty PLN were used as control nanoemulsions. Results are expressed as fold induction over the quiescent EC (in the absence of TNF-α), considered as 1. The data from 3 up to 6 experiments are expressed as mean ± SD. significantly different from TNF-α activated EC.