Low-Dose Steroid Therapy Is Associated with Decreased IL-12 Production in PBMCs of Severe Septic Patients

Table 6

Generalized linear model analysis for the change in IL-12 response to identify independent factors among clinical characteristics and steroid use.

		Change in IL-12 response or (rho)	value
Age	−2.369	0.015	0.727
Sex			0.036
Male	447.838	253.725, −432.0–2059.9
Female	0^†	58.3, −813.8–1023.4
APACHE II	−5.300	−0.316	0.095
Septic shock			0.083
Yes	482.418	176.4, −432.0–2059.9
No	0^†	241.6, −813.8–1928.9
Low-dose steroid			0.003
Yes	−750.743	87.6, −432.0–679.7
No	0^†	352.3, −813.8–2059.9
Mortality			0.574
Yes	−140.572	49.3, −432.0–679.7
No	0^†	224.6, −813.8–2059.9

IL = interleukin; APACHE = Acute Physiology and Chronic Health Evaluation.
Data are presented as the median and range (in pg/mL) for categorical variables or the Spearman rank correlation coefficient (rho) value for continuous variables.
^†0 is set as a reference.