Role of Mitochondria-Associated Endoplasmic Reticulum Membrane in Inflammation-Mediated Metabolic Diseases

Table 1

MAM-resident proteins linked with metabolic and inflammatory diseases.

Proteins	MAM formation	Cell/tissue	Diseases	References
IP3R1, PACS2	Promote	Liver	Insulin resistance	[6]
CypD	Promote	Liver	Insulin resistance	[23]
CypD	Promote	Cardiac muscle	Ischemia-reperfusion injury	[13]
GSK-3β	Promote	Cardiac muscle	Ischemia-reperfusion injury	[24]
Mfn2	Promote	Human airway smooth muscle cells	Asthma	[25]
PML	Promote	Mouse embryonic fibroblast cells (MEFs)	Cancer	[20]
p53	Promote	Various cancer cells	Cancer	[26]
p66Shc	Promote	MAFs (mouse adult fibroblasts)	Cancer	[27]
PTEN	Promote	HEK-293, MEFs	Cancer	[28]
FATE1	Inhibit	Cancer cells	Cancer	[29]
TMX1	Promote	Cancer cells, MEFs	Cancer	[30]
FUS	Promote	Neuronal cells	ALS	[31]
Presenilins	Promote	Brain	Alzheimer’s disease	[10, 32]
Parkin	Promote	Brain	Parkinson’s disease	[33]
α-Synuclein	Promote	Brain	Parkinson’s disease	[34]
Nogo A	Inhibit	Cardiomyocyte	Ischemia-reperfusion injury	[35]
Nogo B	Inhibit	PASMCs, CASMCs, RASMCs	Pulmonary hypertension	[36]
RyR, VDAC	Promote	Cardiac muscle	Aging	[37]

IP3R1: inositol 1,4,5-trisphosphate receptor 1; PACS2: phosphofurin acidic cluster sorting protein 2; CypD: cyclophilin D; GSK-3β: glycogen synthase kinase 3 beta; Mfn2: mitofusin 2; PML: promyelocytic leukemia protein; p53: tumor protein p53; p66sh: 66 kDa isoform of the growth factor adapter Shc; PTEN: phosphatase and tensin homolog; FATE: fetal and adult testis-expressed transcript protein; TMX1: thioredoxin related transmembrane protein 1; FUS: fused in sarcoma; Nogo A and B: reticulon-4/neurite outgrowth inhibitor; RyR: ryanodine receptors; VDAC: voltage-dependent anion channel; ALS: amyotrophic lateral sclerosis; PASMCs: porcine aortic smooth muscle cell; CASMCs: chicken aortic smooth muscle cells; RASMCs: rat aortic smooth muscle cell.