Histamine and Immune Biomarkers in CNS Disorders

Figure 5

Bigenic genotype (APOE + PSEN1)-related histamine levels in Alzheimer’s disease. Concentration of blood histamine in patients with Alzheimer’s disease (AD) according to their bigenic genotypes integrating APOE + Presenilin-1 (PSEN1) in a single haplotype. Haplotype frequencies: 3311 (APOE-3/3 + PSEN1-1/1): 16%; 3312 (APOE-3/3 + PSEN1-1/2): 27%; 3322 (APOE-3/3 + PSEN1-2/2): 10%; 3411 (APOE-3/3 + PSEN1-1/1): 12%; 3412 (APOE-3/4 + PSEN1-1/2): 20%; 3422 (APOE-3/4 + PSEN1-2/2): 5.5%; 4411 (APOE-4/4 + PSEN1-1/1): 5.5%; 4412 (APOE-4/4 + PSEN1-1/2): 4%.