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Mediators of Inflammation
Volume 2016, Article ID 1927348, 9 pages
Review Article

Epidermal Growth Factor and Intestinal Barrier Function

1College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China
2Hunan Co-Innovation Center of Animal Production Safety, Changsha 410128, China
3Hunan Polytechnic of Environment and Biology, Hengyang 421005, China

Received 5 April 2016; Accepted 26 June 2016

Academic Editor: Dianne Cooper

Copyright © 2016 Xiaopeng Tang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Epidermal growth factor (EGF) is a 53-amino acid peptide that plays an important role in regulating cell growth, survival, migration, apoptosis, proliferation, and differentiation. In addition, EGF has been established to be an effective intestinal regulator helping to protect intestinal barrier integrity, which was essential for the absorption of nutrients and health in humans and animals. Several researches have demonstrated that EGF via binding to the EGF receptor and subsequent activation of Ras/MAPK, PI3K/AKT, PLC-γ/PKC, and STATS signal pathways regulates intestinal barrier function. In this review, the relationship between epidermal growth factor and intestinal development and intestinal barrier is described, to provide a better understanding of the effects of EGF on intestine development and health.