Dietary Cocoa Powder Improves Hyperlipidemia and Reduces Atherosclerosis in apoE Deficient Mice through the Inhibition of Hepatic Endoplasmic Reticulum Stress

Figure 3

Representative micrographs of atherosclerotic lesions of the aortic root and gene expression changes in the aortas. (a) Aortic root sections are stained with hematoxylin-eosin (H&E) and oil red O (ORO). Quantitative analysis of aortic root lesion areas is shown in the right. for each group. (b) Gene expression changes in the aortas of the high cocoa powder group relative to the control group. for each group (pooled samples). Bcl2: B-cell leukemia/lymphoma 2; Fas: tumor necrosis factor receptor superfamily, member 6; Bcl2a1: Bcl2-related protein a1; LPL: lipoprotein lipase; PPARγ: peroxisome proliferator-activated receptor gamma; Fabp3: fatty acid binding protein 3; PLIN2: perilipin 2; IL-1α: interleukin-1 alpha; Nr1h3: nuclear receptor subfamily 1, group H, member 3; Selp: selectin P; Cdh5: cadherin 5. Data are expressed as the mean ± SEM. , versus control.

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