Mediators of Inflammation / 2016 / Article / Tab 1

Research Article

Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema

Table 1

The effect of acute hypoxic exposure on inflammatory markers and physiological parameters with and without dexamethasone prophylaxis.

No high altitude illness prophylaxisDexamethasone prophylaxis (hypoxia − normoxia)
NormoxiaHypoxiaNormoxiaHypoxiaNo prophylaxisDexamethasone prophylaxis

Heart rate (1/min)66 1082 12<0.00174 1468 160.6516 12−7 21<0.01
SaO2 (%)96 176 6<0.00196 187 3<0.01−20 6−9 3<0.001
PaO2 (kPa)12.2 1.65.3 0.6<0.00111.4 1.46.5 0.7<0.01−7.1 1.3−4.9 1.1<0.001
LLS-AMS 1 15 3<0.0011 14 2<0.014 33 20.13
 (i) SA-HA0 01 1<0.0010 00 10.481 10 10.03
 (ii) SA-GI0 00 10.0010 00 010 10 00.07
 (iii) SA-FT0 01 1<0.0010 01 10.131 10 10.14
 (iv) SA-DZ0 01 1<0.0010 00 00.351 10 00.11
 (v) SA-SL1 12 1<0.0010 12 10.0051 12 10.08
 (vi) SA-FN0 01 1<0.0010 00 00.151 10 00.03
 (vii) CA-MS0 00 0<0.0010 00 00.650 00 00.002
 (viii) CA-AT0 00 0<0.0010 00 00.650 00 00.002
 (ix) CA-ED0 00 1<0.0010 00 00.650 10 00.002
suPAR (ng/mL)1.9 0.42.3 0.5<0.0012.0 0.32.0 0.30.610.3 0.30.0 0.30.001
CRP (mg/L)0.7 0.53.6 4.6<0.0012.4 3.11.9 2.60.213.0 4.5−0.5 1.1<0.001
IL-6 (ng/L)0.8 0.43.3 4.9<0.0011.0 0.70.6 0.60.322.7 5.0−0.4 1.1<0.001

Values are given as mean SD. SaO2: oxygen saturated hemoglobin fraction and LLS-AMS: Lake Louise score for acute mountain sickness; the cutoff value for the presence of AMS is defined as LLS-AMS ≥ 5 [29, 30]; LLS-AMS self-assessment subscores (scale from 0 to 3): SA-HA: self-assessment headache subscore, SA-GI: self-assessment gastrointestinal subscore, SA-FT: self-assessment fatigue subscore, SA-DZ: self-assessment dizziness subscore, SA-SL: self-assessment sleep quality subscore, and SA-FN: self-assessment global functionality subscore; LLS-AMS clinical assessment subscores: CA-MS: clinical assessment mental status subscore (scale from 0 to 4), CA-AT: clinical assessment ataxia subscore (scale from 0 to 4), and CA-ED: clinical assessment edema subscore (scale from 0 to 2).