Inhibition of Macrophage Migration Inhibitory Factor Protects against Inflammation and Matrix Deposition in Kidney Tissues after Injury

<div>Matrix deposition and MIF expression were enhanced in IRI kidneys. (a) HE and Masson staining revealed marked inflammatory cell infiltration and interstitial injury in IRI kidneys tissues of BUO rats. Bar: 50 <i>μ</i>m. (b) Gene expression of type III collagen in IRI kidneys was upregulated. (c) IRI induced the upregulation of TGF-<i>β</i>1 levels in IRI kidneys. (d) IRI induced upregulated expression of MIF in IRI kidneys. (e) Increased expression of MIF and CD68 in kidneys of IRI rats. Bar: 50 <i>μ</i>m.</div>

Mediators of Inflammation

fig3

Figure 3

Figure 3: Inhibition of Macrophage Migration Inhibitory Factor Protects against Inflammation and Matrix Deposition in Kidney Tissues after Injury 