Inhibition of Macrophage Migration Inhibitory Factor Protects against Inflammation and Matrix Deposition in Kidney Tissues after Injury

<div>EMT and matrix deposition in AA-treated TECs. (a) Immunofluorescence staining revealed enhanced expression of type III collagen and <i>α</i>-SMA and decreased expression of E-cadherin in AA-treated NRK-52E cells. Bar: 100 <i>μ</i>m. (b) qRT-PCR assay showed that the mRNA expression of Col1<i>α</i>1, Col3<i>α</i>1, and <i>α</i>-SMA was upregulated in NRK-52E cells after AA treatment, and the expression of ZO-1, E-cadherin, and BMP-7 was downregulated.</div>

Mediators of Inflammation

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Figure 4

Figure 4: Inhibition of Macrophage Migration Inhibitory Factor Protects against Inflammation and Matrix Deposition in Kidney Tissues after Injury 