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Mediators of Inflammation
Volume 2016, Article ID 2193210, 6 pages
Research Article

Klotho Contributes to Pravastatin Effect on Suppressing IL-6 Production in Endothelial Cells

1Department of Clinical Laboratory, Nanjing Children’s Hospital, Nanjing Medical University, Nanjing 210008, China
2Jiangsu Key Laboratory of Pediatrics, Nanjing 210029, China
3State Key Laboratory of Protein and Plant Gene Research, College of Life Science, Peking University, Beijing 100871, China

Received 12 October 2015; Revised 19 January 2016; Accepted 1 February 2016

Academic Editor: Ulrich Eisel

Copyright © 2016 Weiwei Xia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [8 citations]

The following is the list of published articles that have cited the current article.

  • Rik Mencke, and Jan-Luuk Hillebrands, “The Role of the Anti-Ageing Protein Klotho in Vascular Physiology and Pathophysiology,” Ageing Research Reviews, 2016. View at Publisher · View at Google Scholar
  • Hannes Olauson, Rik Mencke, Jan-Luuk Hillebrands, and Tobias E. Larsson, “Tissue expression and source of circulating αKlotho,” Bone, 2017. View at Publisher · View at Google Scholar
  • Carolin Hoyer, Alexander Sartorius, Suna Su Aksay, Jan Malte Bumb, Christoph Janke, Manfred Thiel, Dieter Haffner, Maren Leifheit-Nestler, and Laura Kranaster, “Electroconvulsive therapy enhances the anti-ageing hormone Klotho in the cerebrospinal fluid of geriatric patients with major depression,” European Neuropsychopharmacology, 2017. View at Publisher · View at Google Scholar
  • Yue Guo, Xiaodong Zhuang, Zena Huang, Jing Zou, Daya Yang, Xun Hu, Zhimin Du, Lichun Wang, and Xinxue Liao, “Klotho protects the heart from hyperglycemia-induced injury by inactivating ROS and NF-κB-mediated inflammation both in vitro and in vivo,” Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017. View at Publisher · View at Google Scholar
  • Heng-Chih Pan, Kuei-Mei Chou, Chin-Chan Lee, Ning-I Yang, and Chiao-Yin Sun, “Circulating Klotho levels can predict long-term macrovascular outcomes in type 2 diabetic patients,” Atherosclerosis, vol. 276, pp. 83–90, 2018. View at Publisher · View at Google Scholar
  • Wei-Chih Kan, Jean-Yu Hwang, Lea-Yea Chuang, Jinn-Yuh Guh, Yi-Ling Ye, Yu-Lin Yang, and Jau-Shyang Huang, “Effect of osthole on advanced glycation end products-induced renal tubular hypertrophy and role of klotho in its mechanism of action,” Phytomedicine, 2018. View at Publisher · View at Google Scholar
  • Emilio González-Reimers, Lucía Romero-Acevedo, Elisa Espelosín-Ortega, M Candelaria Martín-González, Geraldine Quintero-Platt, Pedro Abreu-González, María José de-la-Vega-Prieto, Daniel Martínez-Martínez, and Francisco Santolaria-Fernández, “Soluble Klotho and Brain Atrophy in Alcoholism,” Alcohol and Alcoholism, 2018. View at Publisher · View at Google Scholar
  • Hong-Jing Zhou, Hui Li, Meng-Qi Shi, Xiao-Na Mao, Dong-Ling Liu, Yi-Ran Chang, Yu-Miao Gan, Xi Kuang, and Jun-Rong Du, “Protective Effect of Klotho against Ischemic Brain Injury Is Associated with Inhibition of RIG-I/NF-κB Signaling,” Frontiers in Pharmacology, vol. 8, 2018. View at Publisher · View at Google Scholar