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Mediators of Inflammation
Volume 2016 (2016), Article ID 2347938, 12 pages
http://dx.doi.org/10.1155/2016/2347938
Research Article

The Vascular Endothelial Growth Factors-Expressing Character of Mesenchymal Stem Cells Plays a Positive Role in Treatment of Acute Lung Injury In Vivo

1Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, No. 87 Dingjiaqiao Road, Nanjing, Jiangsu 210009, China
2School of Medicine, Southeast University, No. 87 Dingjiaqiao Road, Nanjing, Jiangsu 210009, China

Received 7 January 2016; Accepted 3 May 2016

Academic Editor: Mirella Giovarelli

Copyright © 2016 Yi Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. “Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome,” The New England Journal of Medicine, vol. 342, no. 18, pp. 1301–1308, 2000. View at Publisher · View at Google Scholar · View at Scopus
  2. H. P. Wiedemann, A. P. Wheeler, G. R. Bernard et al., “Comparison of two fluid-management strategies in acute lung injury,” The New England Journal of Medicine, vol. 354, no. 24, pp. 2564–2575, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. C. Guérin, J. Reignier, J.-C. Richard et al., “Prone positioning in severe acute respiratory distress syndrome,” The New England Journal of Medicine, vol. 368, no. 23, pp. 2159–2168, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. S. L. Hu, H. L. He, C. Pan et al., “The effect of prone positioning on mortality in patients with acute respiratory distress syndrome: a meta-analysis of randomized controlled trials,” Critical Care, vol. 18, no. 3, article R109, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. L. Papazian, J.-M. Forel, A. Gacouin et al., “Neuromuscular blockers in early acute respiratory distress syndrome,” The New England Journal of Medicine, vol. 363, no. 12, pp. 1107–1116, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. E. Buregeya, R. A. Fowler, D. S. Talmor, T. Twagirumugabe, W. Kiviri, and E. D. Riviello, “Acute respiratory distress syndrome in the global context,” Global Heart, vol. 9, no. 3, pp. 289–295, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. L. B. Ware and M. A. Matthay, “The acute respiratory distress syndrome,” The New England Journal of Medicine, vol. 342, no. 18, pp. 1334–1349, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. X. Liang, Y. Ding, Y. Zhang, H.-F. Tse, and Q. Lian, “Paracrine mechanisms of mesenchymal stem cell-based therapy: current status and perspectives,” Cell Transplantation, vol. 23, no. 9, pp. 1045–1059, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. M. S. H. Ho, S. H. J. Mei, and D. J. Stewart, “The immunomodulatory and therapeutic effects of mesenchymal stromal cells for acute lung injury and sepsis,” Journal of Cellular Physiology, vol. 230, no. 11, pp. 2606–2617, 2015. View at Publisher · View at Google Scholar · View at Scopus
  10. C. Liu, Y. Fan, L. Zhou et al., “Pretreatment of mesenchymal stem cells with angiotensin II enhances paracrine effects, angiogenesis, gap junction formation and therapeutic efficacy for myocardial infarction,” International Journal of Cardiology, vol. 188, no. 1, pp. 22–32, 2015. View at Publisher · View at Google Scholar · View at Scopus
  11. S.-P. Wang, Z.-H. Wang, D.-Y. Peng, S.-M. Li, H. Wang, and X.-H. Wang, “Therapeutic effect of mesenchymal stem cells in rats with intracerebral hemorrhage: reduced apoptosis and enhanced neuroprotection,” Molecular Medicine Reports, vol. 6, no. 4, pp. 848–854, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. T. Okazaki, T. Magaki, M. Takeda et al., “Intravenous administration of bone marrow stromal cells increases survivin and Bcl-2 protein expression and improves sensorimotor function following ischemia in rats,” Neuroscience Letters, vol. 430, no. 2, pp. 109–114, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. J.-M. Tang, J.-N. Wang, L. Zhang et al., “VEGF/SDF-1 promotes cardiac stem cell mobilization and myocardial repair in the infarcted heart,” Cardiovascular Research, vol. 91, no. 3, pp. 402–411, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. J. W. Lee, X. Fang, A. Krasnodembskaya, J. P. Howard, and M. A. Matthay, “Concise review: mesenchymal stem cells for acute lung injury: role of paracrine soluble factors,” STEM CELLS, vol. 29, no. 6, pp. 913–919, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. P. R. Crisostomo, Y. Wang, T. A. Markel, M. Wang, T. Lahm, and D. R. Meldrum, “Human mesenchymal stem cells stimulated by TNF-α, LPS, or hypoxia produce growth factors by an NFκB- but not JNK-dependent mechanism,” American Journal of Physiology—Cell Physiology, vol. 294, no. 3, pp. C675–C682, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. T. Kinnaird, E. Stabile, M. S. Burnett et al., “Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms,” Circulation, vol. 109, no. 12, pp. 1543–1549, 2004. View at Google Scholar
  17. A.-R. Liu, L. Liu, S. Chen et al., “Activation of canonical wnt pathway promotes differentiation of mouse bone marrow-derived MSCs into type II alveolar epithelial cells, confers resistance to oxidative stress, and promotes their migration to injured lung tissue in vitro,” Journal of Cellular Physiology, vol. 228, no. 6, pp. 1270–1283, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. H. He, L. Liu, Q. Chen et al., “Mesenchymal stem cells overexpressing angiotensin-converting enzyme 2 rescue lipopolysaccharide-induced lung injury,” Cell Transplantation, vol. 24, no. 9, pp. 1699–1715, 2015. View at Publisher · View at Google Scholar · View at Scopus
  19. M. A. Matthay, “Therapeutic potential of mesenchymal stromal cells for acute respiratory distress syndrome,” Annals of the American Thoracic Society, vol. 12, supplement 1, pp. S54–S57, 2015. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Barratt, A. R. Medford, and A. B. Millar, “Vascular endothelial growth factor in acute lung injury and acute respiratory distress syndrome,” Respiration, vol. 87, no. 4, pp. 329–342, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Song, H. Lu, X. Zheng, and X. Huang, “Effects of vascular endothelial growth factor in recovery phase of acute lung injury in mice,” Lung, vol. 193, no. 6, pp. 1029–1036, 2015. View at Publisher · View at Google Scholar
  22. L. Zhang, H. Liu, Y.-M. Peng, Y.-Y. Dai, and F.-Y. Liu, “Vascular endothelial growth factor increases GEnC permeability by affecting the distributions of occludin, ZO-1 and tight juction assembly,” European Review for Medical and Pharmacological Sciences, vol. 19, no. 14, pp. 2621–2627, 2015. View at Google Scholar · View at Scopus
  23. R. Madonna, L. Petrov, M. A. Teberino et al., “Transplantation of adipose tissue mesenchymal cells conjugated with VEGF-releasing microcarriers promotes repair in murine myocardial infarction,” Cardiovascular Research, vol. 108, no. 1, pp. 39–49, 2015. View at Publisher · View at Google Scholar · View at Scopus
  24. Y. Kim, S. H. Jo, W. H. Kim, and O. Kweon, “Antioxidant and anti-inflammatory effects of intravenously injected adipose derived mesenchymal stem cells in dogs with acute spinal cord injury,” Stem Cell Research & Therapy, vol. 6, no. 1, article 299, 2015. View at Publisher · View at Google Scholar
  25. Y.-M. Pers, M. Ruiz, D. Noël, and C. Jorgensen, “Mesenchymal stem cells for the management of inflammation in osteoarthritis: state of the art and perspectives,” Osteoarthritis and Cartilage, vol. 23, no. 11, pp. 2027–2035, 2015. View at Publisher · View at Google Scholar · View at Scopus
  26. F. F. Cruz, Z. D. Borg, M. Goodwin et al., “Systemic administration of human bone marrow-derived mesenchymal stromal cell extracellular vesicles ameliorates Aspergillus hyphal extract-induced allergic airway inflammation in immunocompetent mice,” Stem Cells Translational Medicine, vol. 4, no. 11, pp. 1302–1316, 2015. View at Publisher · View at Google Scholar · View at Scopus
  27. A. Karihaloo, S. A. Karumanchi, W. L. Cantley, S. Venkatesha, L. G. Cantley, and S. Kale, “Vascular endothelial growth factor induces branching morphogenesis/ tubulogenesis in renal epithelial cells in a neuropilin-dependent fashion,” Molecular and Cellular Biology, vol. 25, no. 17, pp. 7441–7448, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. Y.-G. Kim, S.-I. Suga, D.-H. Kang et al., “Vascular endothelial growth factor accelerates renal recovery in experimental thrombotic microangiopathy,” Kidney International, vol. 58, no. 6, pp. 2390–2399, 2000. View at Publisher · View at Google Scholar · View at Scopus
  29. K. R. S. Brown, K. M. England, K. L. Goss, J. M. Snyder, and M. J. Acarregui, “VEGF induces airway epithelial cell proliferation in human fetal lung in vitro,” American Journal of Physiology—Lung Cellular and Molecular Physiology, vol. 281, no. 4, pp. L1001–L1010, 2001. View at Google Scholar · View at Scopus
  30. V. Compernolle, K. Brusselmans, T. Acker et al., “Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice,” Nature Medicine, vol. 8, no. 7, pp. 702–710, 2002. View at Publisher · View at Google Scholar · View at Scopus
  31. G. D. Yancopoulos, S. Davis, N. W. Gale, J. S. Rudge, S. J. Wiegand, and J. Holash, “Vascular-specific growth factors and blood vessel formation,” Nature, vol. 407, no. 6801, pp. 242–248, 2000. View at Publisher · View at Google Scholar · View at Scopus
  32. R. J. Kaner, J. V. Ladetto, R. Singh, N. Fukuda, M. A. Matthay, and R. G. Crystal, “Lung overexpression of the vascular endothelial growth factor gene induces pulmonary edema,” American Journal of Respiratory Cell and Molecular Biology, vol. 22, no. 6, pp. 657–664, 2000. View at Publisher · View at Google Scholar · View at Scopus
  33. K. Tang, H. B. Rossiter, P. D. Wagner, and E. C. Breen, “Lung-targeted VEGF inactivation leads to an emphysema phenotype in mice,” Journal of Applied Physiology, vol. 97, no. 4, pp. 1559–1566, 2004. View at Publisher · View at Google Scholar · View at Scopus
  34. G. D. Perkins, J. Roberts, D. F. McAuley et al., “Regulation of vascular endothelial growth factor bioactivity in patients with acute lung injury,” Thorax, vol. 60, no. 2, pp. 153–158, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. D. R. Thickett, L. Armstrong, and A. B. Millar, “A role for vascular endothelial growth factor in acute and resolving lung injury,” American Journal of Respiratory and Critical Care Medicine, vol. 166, no. 10, pp. 1332–1337, 2002. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Mura, C. C. Dos Santos, D. Stewart, and M. Liu, “Vascular endothelial growth factor and related molecules in acute lung injury,” Journal of Applied Physiology, vol. 97, no. 5, pp. 1605–1617, 2004. View at Publisher · View at Google Scholar · View at Scopus
  37. B. Maitre, S. Boussat, D. Jean et al., “Vascular endothelial growth factor synthesis in the acute phase of experimental and clinical lung injury,” European Respiratory Journal, vol. 18, no. 1, pp. 100–106, 2001. View at Publisher · View at Google Scholar · View at Scopus