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Mediators of Inflammation
Volume 2016, Article ID 2348968, 14 pages
Review Article

Evidences of Herbal Medicine-Derived Natural Products Effects in Inflammatory Lung Diseases

1Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Federal University of São Paulo, Diadema–SP 09972-270, Brazil
2School of Medicine, University of São Paulo, São Paulo–SP 01246903, Brazil
3Instituto de Saúde e Sociedade, Federal University of São Paulo, Santos–SP 11015-020, Brazil

Received 18 March 2016; Accepted 7 June 2016

Academic Editor: Chang-Shik Yin

Copyright © 2016 Fernanda Paula R. Santana et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Pulmonary inflammation is a hallmark of many respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and acute respiratory syndrome distress (ARDS). Most of these diseases are treated with anti-inflammatory therapy in order to prevent or to reduce the pulmonary inflammation. Herbal medicine-derived natural products have been used in folk medicine and scientific studies to evaluate the value of these compounds have grown in recent years. Many substances derived from plants have the biological effects in vitro and in vivo, such as flavonoids, alkaloids, and terpenoids. Among the biological activities of natural products derived from plants can be pointed out the anti-inflammatory, antiviral, antiplatelet, antitumor anti-allergic activities, and antioxidant. Although many reports have evaluated the effects of these compounds in experimental models, studies evaluating clinical trials are scarce in the literature. This review aims to emphasize the effects of these different natural products in pulmonary diseases in experimental models and in humans and pointing out some possible mechanisms of action.