Research Article
Walker 256 Tumor Growth Suppression by Crotoxin Involves Formyl Peptide Receptors and Lipoxin A4
Figure 3
Effect of CTX on plasma levels of LXA4 and 15-epi-LXA4 in Walker 256 tumor-bearing rats. Not tumor-bearing (NT) or Walker 256 tumor-bearing rats were s.c. daily treated with saline (vehicle control) or CTX (18 µg per rat), during 5 days (first injection on day 1, immediately after tumor cell inoculation or same volume of saline). Rats were also treated with Boc-2 (5 μg per rat /1 mL, i.p.) or same volume of saline, daily, during 5 days, 30 minutes before the s.c. injection of CTX or saline. On the fifth day of treatments, the animals were anesthetized for the collection of blood and plasma was obtained to determine (a) LXA4 or (b) 15-epi-LXA4 levels. Each point represents the mean ± SEM of 5 rats. , significantly different from mean values for saline injected rats after cell injection. , significantly different from mean values for the Boc-2 + CTX group.
| (a) Lipoxin A4 |
| (b) 15-epi-lipoxin A4 |