Blockade of PLD2 Ameliorates Intestinal Mucosal Inflammation of Inflammatory Bowel Disease

Figure 2

PLD2 is mainly expressed in neutrophils. (a) Expression of PLD2 in different subsets of immune cells. Peripheral neutrophils, CD20⁺ B cells, CD8⁺ T cells, CD4⁺ T cells, and CD14⁺ monocytes (1 × 10⁶) were isolated from healthy donors (), and expression of PLD2 was detected by qRT-PCR. , , and versus CD14⁺ monocytes. (b) Neutrophils were isolated from peripheral blood of patients with A-CD (), R-CD (), A-UC (), R-UC (), and HC (). Expression of PLD2 mRNA was examined by qRT-PCR. , , and versus HC. Gene expression was normalized to GAPDH in each group.

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