Blockade of PLD2 Ameliorates Intestinal Mucosal Inflammation of Inflammatory Bowel Disease

Figure 4

Anti-TNF therapy downregulates PLD2 expression. (a) Patients with A-CD () were treated with anti-TNF mAb (IFX, 5 mg/kg) as indicated. Intestinal mucosal biopsies were collected before and at week 12 after the first infusion. Expression of PLD2 mRNA in intestinal mucosa was detected by qRT-PCR. versus that before IFX treatment. ((b) and (c)) Fresh colonic biopsies were harvested from inflamed mucosa in patients with active CD ((b) ) or active UC ((c) ) and cultured in vitro with IFX or control human IgG (HIg) (50 μg/mL) for 24 h. Expression of PLD2 mRNA was detected by qRT-PCR. and versus controls.

(a)

(b)

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