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Mediators of Inflammation
Volume 2016, Article ID 2543070, 14 pages
Research Article

Blockade of PLD2 Ameliorates Intestinal Mucosal Inflammation of Inflammatory Bowel Disease

Department of Gastroenterology, The Shanghai Tenth People’s Hospital of Tongji University, Shanghai 200072, China

Received 11 May 2016; Revised 15 August 2016; Accepted 21 August 2016

Academic Editor: Nona Janikashvili

Copyright © 2016 Guangxi Zhou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

In the supplementary materials, we examined neutrophil profiles in IBD patients. We observed that percentage and absolute numbers of neutrophils were increased in peripheral blood of IBD patients, and neutrophil expression was enhanced in inflamed mucosa of IBD patients. Moreover, PLD2 expression was markedly increased in inflamed mucosa and bone marrow-derived neutrophils in mice with DSS-induced colitis. In addition, information about patients with IBD and healthy donors were listed in supplementary table 1.

  1. Supplementary Material