Central Interleukin-1β Suppresses the Nocturnal Secretion of Melatonin

Figure 6

The effects of icv. injection of interleukin- (IL-) 1β (50 μg/animal) or Ringer’s solution (50 μL) on the relative gene expression (mean ± SEM; animals per group) of IL-1β (a), interleukin 1 type 1 receptor (IL-1R1, (b)), interleukin 1 type 2 receptor (IL-1R2, (c)), and interleukin 1 receptor antagonist (IL-1RN, (d)) in ewes during the short night (SN, May/June) and long night (LN, November/December) photoperiods. All data presented in the figure were normalised to the average relative level of IL-1R2 gene expression measured in the control ewes from the SN photoperiod, which was set to 1.0. Different capital letters indicate significant () differences according to a two-way ANOVA followed by Tukey’s post hoc test.

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