Central Interleukin-1β Suppresses the Nocturnal Secretion of Melatonin

Figure 7

The effects of icv. injection of interleukin- (IL-) 1β (50 μg/animal) or Ringer’s solution (50 μL) on the relative gene expression (mean ± SEM; animals per group) of IL-6 (a), interleukin 6 receptor (IL6R, (b)), and interleukin 6 signal transducer (IL6ST, (c)) in ewes during the short night (SN, May/June) and long night (LN, November/December) photoperiods. All data presented in the figure were normalised to the average relative level of IL-6 gene expression in the control ewes from the SN photoperiod, which was set to 1.0. Different capital letters indicate significant () differences according to a two-way ANOVA followed by Tukey’s post hoc test.

(a)

(b)

(c)