Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2016, Article ID 2684321, 8 pages
http://dx.doi.org/10.1155/2016/2684321
Research Article

Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis

1Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
2Institute of Military Veterinary Medicine, Academy of Military Medical Science, Changchun 130122, China
3Northwest Plateau Institute of Biology, Chinese Academy of Sciences, Xining 810001, China

Received 8 March 2016; Accepted 29 May 2016

Academic Editor: Lawrence Cohen

Copyright © 2016 Wei Zheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. A. Heneghan and I. G. McFarlane, “Current and novel immunosuppressive therapy for autoimmune hepatitis,” Hepatology, vol. 35, no. 1, pp. 7–13, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. S. D. Stan, S. V. Singh, and R. E. Brand, “Chemoprevention strategies for pancreatic cancer,” Nature Reviews Gastroenterology and Hepatology, vol. 7, no. 6, pp. 347–356, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Bilzer, F. Roggel, and A. L. Gerbes, “Role of Kupffer cells in host defense and liver disease,” Liver International, vol. 26, no. 10, pp. 1175–1186, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. Y.-F. Liaw, C.-S. Lee, S.-L. Tsai et al., “T-cell-mediated autologous hepatocytotoxicity in patients with chronic hepatitis C virus infection,” Hepatology, vol. 22, no. 5, pp. 1368–1373, 1995. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Napoli, G. A. Bishop, P. H. McGuinness, D. M. Painter, and G. W. McCaughan, “Progressive liver injury in chronic hepatitis C infection correlates with increased intrahepatic expression of Th1-associated cytokines,” Hepatology, vol. 24, no. 4, pp. 759–765, 1996. View at Publisher · View at Google Scholar · View at Scopus
  6. G. Tiegs, J. Hentschel, and A. Wendel, “A T cell-dependent experimental liver injury in mice inducible by concanavalin A,” The Journal of Clinical Investigation, vol. 90, no. 1, pp. 196–203, 1992. View at Publisher · View at Google Scholar · View at Scopus
  7. F. Hong, B. Jaruga, W. H. Kim et al., “Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS,” The Journal of Clinical Investigation, vol. 110, no. 10, pp. 1503–1513, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. C.-T. Tu, B. Han, H.-C. Liu, and S.-C. Zhang, “Curcumin protects mice against concanavalin A-induced hepatitis by inhibiting intrahepatic intercellular adhesion molecule-1 (ICAM-1) and CXCL10 expression,” Molecular and Cellular Biochemistry, vol. 358, no. 1-2, pp. 53–60, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. S. B. Yee, J. R. Harkema, P. E. Ganey, and R. A. Roth, “The coagulation system contributes to synergistic liver injury from exposure to monocrotaline and bacterial lipopolysaccharide,” Toxicological Sciences, vol. 74, no. 2, pp. 457–469, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. S. B. Yee, P. E. Ganey, and R. A. Roth, “The role of kupffer cells and TNF-α in monocrotaline and bacterial lipopolysaccharide-induced liver injury,” Toxicological Sciences, vol. 71, no. 1, pp. 124–132, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. S. B. Yee, U. M. Hanumegowda, J. A. Hotchkiss, P. E. Ganey, and R. A. Roth, “Role of neutrophils in the synergistic liver injury from monocrotaline and bacterial lipopolysaccharide exposure,” Toxicological Sciences, vol. 72, no. 1, pp. 43–56, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Shen, J. Lu, P. Cheng et al., “Ethyl pyruvate pretreatment attenuates concanavalin a-induced autoimmune hepatitis in mice,” PLoS ONE, vol. 9, no. 2, Article ID e87977, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Kusters, F. Gantner, G. Kunstle, and G. Tiegs, “Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A,” Gastroenterology, vol. 111, no. 2, pp. 462–471, 1996. View at Publisher · View at Google Scholar · View at Scopus
  14. J. G. Kusters, M. M. Gerrits, J. A. G. Van Strijp, and C. M. J. E. Vandenbroucke-Grauls, “Coccoid forms of Helicobacter pylori are the morphologic manifestation of cell death,” Infection and Immunity, vol. 65, no. 9, pp. 3672–3679, 1997. View at Google Scholar · View at Scopus
  15. R.-B. Ding, K. Tian, L.-L. Huang et al., “Herbal medicines for the prevention of alcoholic liver disease: a review,” Journal of Ethnopharmacology, vol. 144, no. 3, pp. 457–465, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Hu, S. Wang, X. Wu et al., “Chinese herbal medicine-derived compounds for cancer therapy: a focus on hepatocellular carcinoma,” Journal of Ethnopharmacology, vol. 149, no. 3, pp. 601–612, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. N. Rolando, J. Wade, M. Davalos, J. Wendon, J. Philpott-Howard, and R. Williams, “The systemic inflammatory response syndrome in acute liver failure,” Hepatology, vol. 32, no. 4, part 1, pp. 734–739, 2000. View at Google Scholar · View at Scopus
  18. C. G. Antoniades, P. A. Berry, J. A. Wendon, and D. Vergani, “The importance of immune dysfunction in determining outcome in acute liver failure,” Journal of Hepatology, vol. 49, no. 5, pp. 845–861, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Mizuhara, E. O'Neill, N. Seki et al., “T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin 6,” Journal of Experimental Medicine, vol. 179, no. 5, pp. 1529–1537, 1994. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Chen, S. M. F. Akbar, M. Abe, Y. Hiasa, and M. Onji, “Immunosuppressive functions of hepatic myeloid-derived suppressor cells of normal mice and in a murine model of chronic hepatitis B virus,” Clinical and Experimental Immunology, vol. 166, no. 1, pp. 134–142, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Yamano, L. A. DeCicco, and L. E. Rikans, “Attenuation of cadmium-induced liver injury in senescent male fischer 344 rats: role of kupffer cells and inflammatory cytokines,” Toxicology and Applied Pharmacology, vol. 162, no. 1, pp. 68–75, 2000. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Ostrand-Rosenberg and P. Sinha, “Myeloid-derived suppressor cells: linking inflammation and cancer,” The Journal of Immunology, vol. 182, no. 8, pp. 4499–4506, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. P. Ray, M. Arora, S. L. Poe, and A. Ray, “Lung myeloid-derived suppressor cells and regulation of inflammation,” Immunologic Research, vol. 50, no. 2-3, pp. 153–158, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. S. K. Bunt, L. Yang, P. Sinha, V. K. Clements, J. Leips, and S. Ostrand-Rosenberg, “Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression,” Cancer Research, vol. 67, no. 20, pp. 10019–10026, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. G. Liu, Y. Bi, R. Wang et al., “Targeting S1P1 receptor protects against murine immunological hepatic injury through myeloid-derived suppressor cells,” Journal of Immunology, vol. 192, no. 7, pp. 3068–3079, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. P. Sinha, V. K. Clements, S. K. Bunt, S. M. Albelda, and S. Ostrand-Rosenberg, “Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response,” The Journal of Immunology, vol. 179, no. 2, pp. 977–983, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. M. G. Kelly, A. B. Alvero, R. Chen et al., “TLR-4 signaling promotes tumor growth and paclitaxel chemoresistance in ovarian cancer,” Cancer Research, vol. 66, no. 7, pp. 3859–3868, 2006. View at Publisher · View at Google Scholar · View at Scopus