Shikonin Attenuates Concanavalin A-Induced Acute Liver Injury in Mice via Inhibition of the JNK Pathway

Figure 2

Effects of shikonin on liver function and pathology of mice with ConA-induced acute hepatitis. (a) The levels of serum ALT and AST changed depending on the shikonin dose, 7.5 mg/kg or 12.5 mg/kg. Data are given as means ± SD (, for NC versus ConA, for ConA + shikonin (7.5) versus ConA, and for ConA + shikonin (12.5) versus ConA). (b) The necrotic and edematous area stained with hematoxylin and eosin and used for the liver sections was analyzed with Image-Pro Plus 6.0 (magnification, ×200). The results show statistically significant differences among the different groups (, for NC versus ConA, for ConA + shikonin (7.5) versus ConA, and for ConA + shikonin (12.5) versus ConA).

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