SOCS1 Mimetic Peptide Suppresses Chronic Intraocular Inflammatory Disease (Uveitis)

Figure 1

SOCS1-KIR suppressed inflammation in the anterior segment of the eye during EAU. (a) We induced EAU by adoptive transfer of uveitogenic R16-specific T cells and the rats were treated with SOCS1-KIR or scrambled peptide (control). Representative images of the anterior eye segment were taken 6 days after EAU induction using a slit-lamp microscopy system. The images reveal marked inflammation with hazy anterior chamber and obscured pupil in the control rats compared to rats treated with SOCS1-KIR. (b) Clinical scores of the eyes at various time points after induction of EAU. (c) Visualization of longitudinal structure of the anterior eye segment by anterior segment OCT. Representative OCT images taken 8 days after disease induction show markedly increased inflammatory cells (white arrows) in the anterior chamber of rats treated with scrambled peptide compared to rats treated with SOCS1-KIR. (d) Clinical scores of the eyes at day 50 after induction of EAU. Clinical scores and assessment of disease severity were based on changes at the iris vessels and anterior chamber as described in the text. Data presented are the average of six rats per group and results expressed as the mean ± SEM. < 0.05, < 0.005, < 0.001.

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