Doxycycline Inhibits IL-17-Stimulated MMP-9 Expression by Downregulating ERK1/2 Activation: Implications in Myogenic Differentiation

<div>IL-17-stimulated MMP-9 expression is inhibited by Doxycycline. (a) IL-17 induced MMP-9 activation in the presence or absence of 5 or 10 <i>μ</i>g/mL of Doxy determined by zymography. (b) Promoter transactivation induced by IL-17 in the presence or absence of Doxy. (c) IL-17-induced MMP-9 mRNA expression determined by RT-PCR. GAPDH is used as gel loading control.</div>

Mediators of Inflammation

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Figure 4

Figure 4: Doxycycline Inhibits IL-17-Stimulated MMP-9 Expression by Downregulating ERK1/2 Activation: Implications in Myogenic Differentiation 