Increased Kappa/Lambda Hybrid Antibody in Serum Is a Novel Biomarker Related to Disease Activity and Inflammation in Rheumatoid Arthritis

Figure 1

Comparison of levels of κ/λ hybrid antibody in the sera of patients with treatment naïve ERA, established RA, OA, and HC. Serum levels of κ/λ hybrid antibody were measured by enzyme-linked immunosorbent assay in patients with ERA (), established RA (), OA (), and HC (). Serum levels of κ/λ hybrid antibody were both significantly higher in patients with ERA and established RA compared with those in OA ( and , resp.) and HC ( and , resp.). Concentrations of κ/λ hybrids antibody are presented in arbitrary units (AU/mL). Symbols represent individual subjects; solid line was labeled at mean with SEM. values were determined using Mann-Whitney test, , , and .