Interleukin-17A Gene Variability in Patients with Type 1 Diabetes Mellitus and Chronic Periodontitis: Its Correlation with IL-17 Levels and the Occurrence of Periodontopathic Bacteria
Table 2
IL-17A −197A/G (rs2275913) genotype and allele frequencies in healthy controls, patients with CP, T1DM (and the T1DM + CP subgroup).
IL-17A −197
Controls
CP
T1DM
T1DM + CP
Genotype and allele
(%)
(%)
OR (95% CI)
(%)
OR (95% CI)
(%)
OR (95% CI)
AA
18 (11.7)
32 (13.1)
0.56
1.00 (0.52–1.93)
23 (18.4)
0.05
1.93 (0.93–4.00)
6 (15.8)
0.46
1.20 (0.42–3.48)
AG
71 (46.1)
97 (39.8)
0.14
0.77 (0.50–1.19)
59 (47.2)
0.23
1.26 (0.75–2.11)
14 (36.8)
0.25
0.71 (0.33–1.55)
GG
65 (42.2)
115 (47.1)
1.00
43 (34.4)
1.00
18 (47.4)
1.00
AA + AG versus GG
89 versus 65 (57.8/42.2)
129 versus 115 (52.9/47.1)
0.20
0.82 (0.55–1.23)
82 versus 43 (65.6/34.4)
0.11
1.39 (0.85–2.27)
20 versus 18 (52.6/47.4)
0.35
0.81 (0.40–1.65)
A
107 (34.7)
161 (33.0)
0.92 (0.68–1.25)
105 (42.0)
1.36 (0.96–1.92)
26 (34.2)
0.98 (0.58–1.66)
G
201 (65.3)
327 (67.0)
0.33
1.00
145 (58.0)
0.05
1.00
50 (65.8)
0.37
1.00
CI = confidential interval, CP = chronic periodontitis, = number of subjects, OR = odds ratio, and T1DM = diabetes mellitus type 1; value < 0.05 (in comparison with healthy controls).
