Interleukin-17A Gene Variability in Patients with Type 1 Diabetes Mellitus and Chronic Periodontitis: Its Correlation with IL-17 Levels and the Occurrence of Periodontopathic Bacteria
Table 5
The presence of bacteria in correlation with IL-17A −197A/G (rs2275913) polymorphism in patients with CP and T1DM + CP#.
IL-17A −197
CP
CP
T1DM + CP
(%)
(%)
(%)
Genotype and allele
T.f. neg
T.f. pos
P.i. neg
P.i. pos
T.d. neg
T.d. pos
AA
0 (0.0)
24 (15.1)
0.02
6 (8.0)
18 (16.8)
0.07
3 (25.0)
3 (11.5)
0.14
AG
9 (39.1)
63 (39.6)
0.33
31 (41.3)
41 (38.3)
0.51
6 (50.0)
8 (30.8)
0.11
GG
14 (60.9)
72 (45.3)
38 (50.7)
48 (44.9)
3 (25.0)
15 (57.7)
AA + AG versus GG
9 versus 14 (39.1 versus 60.9)
87 versus 72 (54.7 versus 45.3)
0.12
37 versus 38 (49.3 versus 50.7)
59 versus 48 (55.1 versus 44.9)
0.27
9 versus 3 (75.0 versus 25.0)
11 versus 15 (42.3 versus 57.7)
0.06
A
9 (19.6)
111 (34.9)
43 (28.7)
77 (36.0)
12 (50.0)
14 (26.9)
G
37 (80.4)
207 (65.1)
0.03
107 (71.3)
137 (64.0)
0.09
12 (50.0)
38 (73.1)
0.04
IL-17A −197
CP nonsmokers
CP nonsmokers
T1DM + CP nonsmokers
(%)
(%)
(%)
Genotype and allele
T.f. neg
T.f. pos
P.i. neg
P.i. pos
T.d. neg
T.d. pos
AA
0 (0.0)
20 (17.5)
0.06
4 (7.4)
16 (20.8)
0.04
2 (25.0)
3 (13.6)
0.27
AG
8 (47.1)
44 (38.6)
0.59
23 (42.6)
29 (37.7)
0.51
4 (50.0)
7 (31.8)
0.21
GG
9 (52.9)
50 (43.9)
27 (50.0)
32 (41.6)
2 (25.0)
12 (54.5)
AA + AG versus GG
8 versus 9 (47.1 versus 52.9)
64 versus 50 (56.1 versus 43.9)
0.33
27 versus 27 (50.0 versus 50.0)
45 versus 32 (58.5 versus 41.6)
0.22
6 versus 2 (75.0 versus 25.0)
10 versus 12 (45.4 versus 54.5)
0.15
A
8 (23.5)
84 (36.8)
31 (28.7)
61 (39.6)
8 (50.0)
13 (29.5)
G
26 (76.5)
144 (63.2)
0.09
77 (71.3)
93 (60.4)
0.05
8 (50.0)
31 (70.5)
0.12
CP = chronic periodontitis, = number of subjects, neg = negative, pos = positive, T1DM = type 1 diabetes mellitus, P.i. = Prevotella intermedia, T.d. = Treponema denticola, T.f. = Tannerella forsythia, and value < 0.05. #Of the seven periodontal pathogens analyzed, only those with significant differences are shown.
