Placental Growth Factor, Soluble fms-Like Tyrosine Kinase 1, Soluble Endoglin, IL-6, and IL-16 as Biomarkers in Preeclampsia

Table 2

Serum levels of soluble markers analysed in PE and controls.

	⁢Second trimester (first visit)			⁢Third trimester (second visit)
	PE group	CTRL group	value	PE group	CTRL group	value
sEng (ng/mL)	2.78 (.34–5.11)	3.52 (.97–6.15)	0.058	2.75 (.67–6.65)	3.12 (1.04–5.47)	0.000
sFlt1 (pg/mL)	310.22 (9–8077)	142.05 (.009–.67)	0.000	514.23 (1–13557.0)	201.32 (.00–1.17)	0.000
PlGF (pg/mL)	319.31 (27.7–2234.0)	383.07 (21.21–2744.00)	0.001	313.36 (45.50–1559.2)	696.93 (127.22–2123.90)	0.001
sFlt1/PlGF	3.35 (.02–125.45)	.86 (.05–3.78)	0.000	9.62 (.000–297.91)	.51 (.00–4.20)	0.000
IL-6 (pg/mL)	2.62 (.01–58.83)	1.64 (.02–14.42)	0.000	4.57 (.00–76.36)	.01 (.00–.02)	0.000
IL-16 (pg/mL)	698.26 (.00–2001.0)	810.67 (20.80–2001.0)	0.018	882.91 (0.90–2001.0)	1186.72 (.90–2001.0)	0.067

Chi-square test.
Mann–Whitney test.