Placental Growth Factor, Soluble fms-Like Tyrosine Kinase 1, Soluble Endoglin, IL-6, and IL-16 as Biomarkers in Preeclampsia

Table 4

Predictive characteristics of studied markers in relation to their cut-offs.

	Sensitivity (%)	Specificity (%)	Diag acc (%)	PPV (%)	NPV (%)	LR+	LR−
sEng (ng/mL)	62.1	56.8	59.1	52.9	65.6	1.435	0.668
sFlt1 (pg/mL)	44.8	67.6	57.6	52.0	61.0	1.382	0.817
PlGF (pg/mL)	100	47.2	70.8	60.4	100	1.895	0.000
sFlt1/PlGF	96.6	5.7	46.2	40.0	100	1.022	0.621
IL-6 (pg/mL)	27.6	89.2	62.1	66.7	61.1	2.552	0.812
IL-16 (pg/mL)	69.0	67.6	68.2	62.5	73.5	2.126	0.459

Diagnostic accuracy (Diag acc); PPV: positive predictive value, NPV: negative predictive value, LR+: positive likelihood ratio, and LR−: negative likelihood ratio.