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Mediators of Inflammation
Volume 2016, Article ID 3064643, 11 pages
Review Article

Serum Cytokinome Profile Evaluation: A Tool to Define New Diagnostic and Prognostic Markers of Cancer Using Multiplexed Bead-Based Immunoassays

1CROM, Istituto Nazionale Tumori “Fondazione G. Pascale”, IRCCS, Naples, Italy
2Center of Medical Informatics, SIM/AOU, Second University of Naples, Naples, Italy
3Direzione Scientifica, Istituto Nazionale Tumori “Fondazione G. Pascale”, IRCCS, Naples, Italy

Received 12 March 2016; Revised 19 September 2016; Accepted 27 October 2016

Academic Editor: Constantino López-Macías

Copyright © 2016 Francesca Capone et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In recent years, many researchers are focusing their attention on the link between inflammation and cancer. The inflammation is involved in the tumor development and suppression, by stimulating the immune response. In particular, the transition from chronic inflammation to cancer produces angiogenic and growth factors able to repair the tissue and to promote cancer cell survival, implantation, and growth. In this contest, the cytokines contribute to the development of these processes becoming active before and during the inflammatory process and playing an important function at the various disease levels. Thus, these proteins can represent specific markers of tumor development and progression. Therefore the “cytokinome” term is used to indicate the evaluation of cytokine pattern by using an “omics” approach. Newly, specific protein chips of considerable and improved sensitivity are being developed to determine simultaneously several and different cytokines. This can be achieved by a multiplex technology that, through the use of small amounts of serum or other fluids, is used to determine the presence and the levels of underrepresented cytokines. Since this method is an accurate, sensitive, and reproducible cytokine assay, it is already used in many different studies. Thus, this review focuses on the more latest aspects related to cytokinome profile evaluation in different cancers.