Immunity and Tolerance Induced by Intestinal Mucosal Dendritic Cells

Figure 1

Intestinal mucosal dendritic cell and macrophage development and function. Bone marrow resident Granulocyte Macrophage Progenitors (GMP) give rise to Macrophage DC Precursors (MDP). In turn, CDP give rise to peripheral blood monocytes (Mono) and Common DC Progenitors (CDP). Monocytes will migrate to the lamina propria differentiating into CD11b+CX3CR1+ macrophages that directly sample antigens from the intestinal lumen. On the other hand, CDP will give rise to three subpopulations of intestinal lamina propria DCs: CD11b+CD103+, CD11b−CD103+, and CD11b−CD103−. The former two subsets are responsible for sampling antigen and priming naïve T cells into regulatory T cells (Treg) or IL17-producing T cells (Th17).