Anti-Interleukin-1 Beta/Tumor Necrosis Factor-Alpha IgY Antibodies Reduce Pathological Allergic Responses in Guinea Pigs with Allergic Rhinitis

Figure 2

HE staining of lung tissue sections at 8 h in guinea pigs of the healthy control and different treated AR groups (200x). (a) The healthy control group (group C); (b) the AR model group (group M); (c) the 0.1% nonspecific IgY-treated group (group Z₁); (d) the 0.1% anti-TNF-α-treated group (group Z₂); (e) the 0.1% anti-IL-1β-treated group (group Z₃); (f) the 0.1% anti-IL-1β/TNF-α-treated group (group Z₄); and (g) the fluticasone propionate-treated group (group Z₅). Eosinophils infiltration (the green arrows); neutrophils infiltration (the yellow arrows); lymphocytes infiltration (the black arrows); broadening of the alveolar septa (the red arrows); fracture of alveolar septa (the violet arrows). The partial drop of the number of bronchial mucosal epithelial cells and the discharge of intrabronchial secreta (the blue arrows).

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