Blood Genome-Wide Transcriptional Profiles of HER2 Negative Breast Cancers Patients

Table 2

Association between ER, PR status and clinicopathological parameters.

Characteristics	Number of patients (%)	ER+PR+HER2−	ER−PR−HER2−	value
Study population	29 (100%)	15 (51.7%)	14 (48.3%)
Median age (years)		52	51.5	0.41
Menopausal status
Pre	9 (31%)	11	7	0.24
Post	18 (62.1%)	3	6
N/A	2 (6.9%)	1	1
Clinical stage
I-II	13 (44.8%)	6	7	0.71
III	16 (55.2%)	9	7
Tumor size
T1-T2	16 (55.2%)	7	9	0.46
T3-T4	13 (44.8%)	8	5
Lymph nodes
N0	4 (13.8%)	4	0	—
N1	15 (51.7%)	6	9
N2	10 (34.5%)	5	5
Nottingham grading
I-II	16 (55.2%)	12	4	0.009
III	13 (44.8%)	3	10
Stroma
Fibrohyaline	17 (58.6%)	12	5	0.025
Desmoplastic	12 (41.4%)	3	9
Inflammation
No-weak	18 (62.1%)	13	5	0.008
Medium-intense	11 (37.9%)	2	9
Necrosis
Absent	21 (72.4%)	15	6	0.0007
Present	8 (27.6%)	0	8

Two patients with bilateral cancer. The higher value for clinical stage, tumor size, and nodes was considered.