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Mediators of Inflammation
Volume 2016, Article ID 3271579, 8 pages
Research Article

Neuroinflammation Induced by Surgery Does Not Impair the Reference Memory of Young Adult Mice

1Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
2Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China
3Department of Anesthesiology, Shanghai Tenth People’s Hospital, Shanghai, China
4Shanghai Universities Collaborative Innovation Center for Translational Medicine, Shanghai, China

Received 21 June 2016; Revised 13 September 2016; Accepted 21 September 2016

Academic Editor: Giuseppe Valacchi

Copyright © 2016 Yanhua Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Postoperative cognitive dysfunction (POCD) increases morbidity and mortality after surgery. But the underlying mechanism is not clear yet. While age is now accepted as the top one risk factor for POCD, results from studies investigating postoperative cognitive functions in adults have been controversial, and data about the very young adult individuals are lacking. The present study investigated the spatial reference memory, IL-1β, IL-6, and microglia activation changes in the hippocampus in 2-month-old mice after anesthesia and surgery. We found that hippocampal IL-1β and IL-6 increased at 6 hours after surgery. Microglia were profoundly activated in the hippocampus 6 to 24 hours after surgery. However, no significant behavior changes were found in these mice. These results indicate that although anesthesia and surgery led to neuroinflammation, the latter was insufficient to impair the spatial reference memory of young adult mice.