Regulatory T Cell Induced by Poria cocos Bark Exert Therapeutic Effects in Murine Models of Atopic Dermatitis and Food Allergy

Figure 1

Experimental designs for inductions of atopic dermatitis and food allergy. (a) Five-week-old female BALB/c mice were divided into naïve (), sham (), PCB (), and dexamethasone () groups. 25 mg/kg of PCB extract was orally administrated from day 0 to 61. For induction of atopic dermatitis, each 1% DNCB and 10 mg/mL of HDM extract was applied to each ear once a week from day 21 (total six times). (b) Six-week-old female BALB/c mice were divided into naïve (), sham (), PCB (), and dexamethasone () groups. To induce food allergies, mice were immunized with 20 μg OVA and 2 mg Imject Alum by intraperitoneal (i.p.) injection on day 0. From day 17, mice were orally challenged with 50 mg OVA in saline every 3 days, for a total of six times. Next, 25 mg/kg PCB extract was administered orally daily from day 17 to 34.

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