Deubiquitinases: Novel Therapeutic Targets in Immune Surveillance?

Table 1

DUBs involved in TLR, NOD1/2, or inflammasome activation. Knock-out mouse available for these DUBs has been indicated. Mouse model validation of target in which these mice have been used to demonstrate their function on that substrate. This table does not include studies where these mice have been used in other models of inflammation.

DUB	PRR	Target	KO mouse available	Mouse model validation of target	Ref.
USP2a	TLR	TRAF6	Yes	No	[89]
USP4	TLR	TAK1	Yes	No	[90]
USP7	TLR	NF-κB, NEMO	No, lethal	No	[24, 25, 82]
USP10	TLR	NEMO, TRAF6	No, lethal	No	[6, 26, 91]
USP15	TLR	IκBα	Yes	No	[92]
USP18	TLR	TAK1, NEMO	Yes	Yes	[28, 77]
USP20	TLR	TRAF6	No	No	[93]
USP21	TLR	RIPK1	Yes	No	[94, 95]
USP25	TLR	TRAF3	Yes	Yes	[96, 97]
USP31	TLR		Yes	No	[98]
A20	TLR	TRAF6, RIPK1, NEMO	Yes	Yes	[3, 76, 99, 100]
	NOD1/2	RIPK2		Yes	[34]
	NLRP3 inflammasome			Yes	[57, 58]
Cezanne	TLR	TRAF6	Yes	Yes	[101, 102]
OTULIN	TLR	NEMO	No, lethal	No	[103, 104]
	NOD2	RIPK2			[103, 105]
CYLD	TLR	RIPK1, TRAF2, NEMO	Yes	Yes	[12, 72]
MYSM1	TLR	TRAF3, TRAF6	Yes	Yes	[105, 106]
BRCC3	NLRP3 inflammasome	NLRP3	No	No	[51]