Interplay between Cellular and Molecular Inflammatory Mediators in Lung Cancer

Figure 1

Smoke exposure mediated pathogenesis of pulmonary disease. The exposition to cigarette smoke by macrophages leads to release of lysosomal enzymes able to inhibit phagocytosis by macrophages. Activation of alveolar macrophages deregulates expression of adhesive molecules (CD36, CD91, and CD44) and activated RhoA inhibiting efferocytosis. The rapid and sustained inflammation may contribute to the lung injury and tumorigenesis.