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Mediators of Inflammation
Volume 2016 (2016), Article ID 3495173, 4 pages
http://dx.doi.org/10.1155/2016/3495173
Review Article

Diet-Intestinal Microbiota Axis in Osteoarthritis: A Possible Role

Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China

Received 10 June 2016; Accepted 25 July 2016

Academic Editor: Jie Yin

Copyright © 2016 Yusheng Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Intestinal microbiota is highly involved in host physiology and pathology through activity of the microbiome and its metabolic products. Osteoarthritis (OA) is a common form of arthritis characterized by articular cartilage destruction and osteophyte formation. Although various person-level risk factors, such as age, sex, and obesity, have been proposed for the pathogenesis of OA, the underlying links between these person-level factors and OA are still enigmatic. Based on the current understanding in the crosstalk between intestinal microbiota and these risk factors, intestinal microbiota could be considered as a major hidden risk factor that provides a unifying mechanism to explain the involvement of these person-level risk factors in OA.