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Mediators of Inflammation
Volume 2016, Article ID 3541283, 7 pages
http://dx.doi.org/10.1155/2016/3541283
Research Article

NK Cell-Dependent Growth Inhibition of Lewis Lung Cancer by Yu-Ping-Feng, an Ancient Chinese Herbal Formula

1Department of Oncology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China
2Laboratory of Integrative Medicine, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, 1200 Cai Lun Road, Shanghai 201203, China
3Department of Immunology and Pathogenic Biology, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, 1200 Cai Lun Road, Shanghai 201203, China

Received 20 October 2015; Accepted 3 February 2016

Academic Editor: Jyoti J. Watters

Copyright © 2016 Yingbin Luo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Hanahan and R. A. Weinberg, “Hallmarks of cancer: the next generation,” Cell, vol. 144, no. 5, pp. 646–674, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. P. A. Ascierto and F. M. Marincola, “What have we learned from cancer immunotherapy in the last 3 years?” Journal of Translational Medicine, vol. 12, no. 1, article 141, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. X. Chen, L. Yang, G. Zeng, and G. Shen, “The regulatory action of the modified Yu Ping Feng Tang on cellular immunity in mice under amputation-induced stress,” Journal of Traditional Chinese Medicine, vol. 20, no. 4, pp. 302–306, 2000. View at Google Scholar · View at Scopus
  4. X.-T. Chen, J. Li, H.-L. Wang, W.-M. Cheng, L. Zhang, and J.-F. Ge, “Immunomodulating effects of fractioned polysaccharides isolated from Yu-Ping-Feng-Powder in cyclophosphamide-treated mice,” The American Journal of Chinese Medicine, vol. 34, no. 4, pp. 631–641, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. P. M. K. Poon, C. K. Wong, K. P. Fung et al., “Immunomodulatory effects of a traditional Chinese medicine with potential antiviral activity: a self-control study,” The American Journal of Chinese Medicine, vol. 34, no. 1, pp. 13–21, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. C. Y. Q. Du, R. C. Y. Choi, T. T. X. Dong, D. T. W. Lau, and K. W. K. Tsim, “Yu Ping Feng San, an ancient Chinese herbal decoction, regulates the expression of inducible nitric oxide synthase and cyclooxygenase-2 and the activity of intestinal alkaline phosphatase in cultures,” PLoS ONE, vol. 9, no. 6, Article ID e100382, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Y. Q. Du, R. C. Y. Choi, K. Y. Z. Zheng, T. T. X. Dong, D. T. W. Lau, and K. W. K. Tsim, “Yu Ping Feng San, an ancient Chinese herbal decoction containing Astragali Radix, Atractylodis Macrocephalae Rhizoma and Saposhnikoviae Radix, regulates the release of cytokines in murine macrophages,” PLoS ONE, vol. 8, no. 11, Article ID e78622, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. C. Y. Du, K. Y. Z. Zheng, C. W. C. Bi, T. T. X. Dong, H. Lin, and K. W. K. Tsim, “Yu Ping Feng San, an ancient chinese herbal decoction, induces gene expression of anti-viral proteins and inhibits neuraminidase activity,” Phytotherapy Research, vol. 29, no. 5, pp. 656–661, 2015. View at Publisher · View at Google Scholar
  9. R. D. Gentzler and J. D. Patel, “Maintenance treatment after induction therapy in non-small cell lung cancer: latest evidence and clinical implications,” Therapeutic Advances in Medical Oncology, vol. 6, no. 1, pp. 4–15, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. Q. F. Chen, S.-M. Qin, X. Y. Zou et al., “Efficacy of immune regulation in Yupingfeng Granules combined with Bailing Caspsules on chemotherapy lung cancer patients,” Chinese Traditional Patent Medicine, vol. 35, no. 2, pp. 249–251, 2013. View at Publisher · View at Google Scholar
  11. N. W. Zwirner and C. I. Domaica, “Cytokine regulation of natural killer cell effector functions,” Biofactors, vol. 36, no. 4, pp. 274–288, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. G. Landskron, M. De La Fuente, P. Thuwajit, C. Thuwajit, and M. A. Hermoso, “Chronic inflammation and cytokines in the tumor microenvironment,” Journal of Immunology Research, vol. 2014, Article ID 149185, 19 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. S.-C. Chiu, Y.-L. Lai, H.-H. Chang et al., “The therapeutic effect of modified Yu Ping Feng San on idiopathic sweating in end-stage cancer patients during hospice care,” Phytotherapy Research, vol. 23, no. 3, pp. 363–366, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. E. Ames and W. J. Murphy, “Advantages and clinical applications of natural killer cells in cancer immunotherapy,” Cancer Immunology, Immunotherapy, vol. 63, no. 1, pp. 21–28, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. E. Vivier, E. Tomasello, M. Baratin, T. Walzer, and S. Ugolini, “Functions of natural killer cells,” Nature Immunology, vol. 9, no. 5, pp. 503–510, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. I. Cremer, W. H. Fridman, and C. Sautes-Fridman, “Tumor microenvironment in NSCLC suppresses NK cells function,” OncoImmunology, vol. 1, no. 2, pp. 244–246, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Stojanovic and A. Cerwenka, “Natural killer cells and solid tumors,” Journal of Innate Immunity, vol. 3, no. 4, pp. 355–364, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Baginska, E. Viry, J. Paggetti et al., “The critical role of the tumor microenvironment in shaping natural killer cell-mediated anti-tumor immunity,” Frontiers in Immunology, vol. 4, article 490, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Mordoh, E. M. Levy, and M. P. Roberti, “Natural killer cells in human cancer: from biological functions to clinical applications,” Journal of Biomedicine and Biotechnology, vol. 2011, Article ID 676198, 11 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. L. Yang, Y. Pang, and H. L. Moses, “TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression,” Trends in Immunology, vol. 31, no. 6, pp. 220–227, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. H. Ikushima and K. Miyazono, “TGFΒ 2 signalling: a complex web in cancer progression,” Nature Reviews Cancer, vol. 10, no. 6, pp. 415–424, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. S. S. Donatelli, J.-M. Zhou, D. L. Gilvary et al., “TGF-β-inducible microRNA-183 silences tumor-associated natural killer cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 11, pp. 4203–4208, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. R. Sucher, K. Kurz, G. Weiss, R. Margreiter, D. Fuchs, and G. Brandacher, “IDO-mediated tryptophan degradation in the pathogenesis of malignant tumor disease,” International Journal of Tryptophan Research, vol. 3, no. 1, pp. 113–120, 2010. View at Google Scholar · View at Scopus
  24. G. C. Prendergast, C. Smith, S. Thomas et al., “Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer,” Cancer Immunology, Immunotherapy, vol. 63, no. 7, pp. 721–735, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Della Chiesa, S. Carlomagno, G. Frumento et al., “The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function,” Blood, vol. 108, no. 13, pp. 4118–4125, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. N. Sato, Y. Saga, H. Mizukami et al., “Downregulation of indoleamine-2,3-dioxygenase in cervical cancer cells suppresses tumor growth by promoting natural killer cell accumulation,” Oncology Reports, vol. 28, no. 5, pp. 1574–1578, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. R. Liu, H. Zheng, W. Li et al., “Anti-tumor enhancement of Fei-Liu-Ping ointment in combination with celecoxib via cyclooxygenase-2-mediated lung metastatic inflammatory microenvironment in Lewis lung carcinoma xenograft mouse model,” Journal of Translational Medicine, vol. 13, no. 1, article 366, 2015. View at Publisher · View at Google Scholar