CCR9 Is a Key Regulator of Early Phases of Allergic Airway Inflammation

Figure 1

Leukocyte recruitment is impaired in BALF in absence of CCR9. (a) Wild type (WT) and knockout (KO) mice were first sensitized with OVA/alum intraperitoneally. Control animals received saline solution (SS). OVA was aerosolized as indicated. Mice were sacrificed 24 h after the last antigen challenge. (b) Total number of cells from BALF WT and KO mice was quantified. (c) Collected BALF cells were stained with Wright’s stain and lymphocytes (LYM), macrophages (MAC), eosinophils (EOS), and neutrophils (NEU) were distinguished morphologically. (d) OVA-specific IgE was determined by ELISA in serum samples from mice. Data represent mean ± SD and are representative of 4 independent experiments. -4 for each group ( when compared with WT group).

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