Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2016 (2016), Article ID 3635809, 16 pages
http://dx.doi.org/10.1155/2016/3635809
Research Article

CCR9 Is a Key Regulator of Early Phases of Allergic Airway Inflammation

1CBRL, Ciudad de México, Mexico
2Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, 04510 Ciudad de México, Mexico
3Departamento de Patología Experimental, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Tlalpan, 14080 Ciudad de México, Mexico

Received 9 May 2016; Accepted 7 August 2016

Academic Editor: Carolina T. Piñeiro

Copyright © 2016 C. López-Pacheco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure 1. IL-2, IL-6, IL-12, IL-13, IL-17A, IL-23, IFN-g and TGF-b were determined from BAL by ELISA multiarray. CCR9 deficiency modifies the inflammatory cytokine production specially at 6 hours post OVA challenge.

Supplementary Figure 2. CCL25 expression was analyzed in lung tissue by immunohistochemistry at 6 an 24 hours after challenge. Images demonstrate that CCL25 peaks is at 6 hours and is dependent on CCR9 expression.

Supplementary Figure 3. Phenotypic analysis of eosinophils was performed by FACS in BAL-derived cells. CCR9 expression was determined and Siglec was not altered in the absence of CCR9.

  1. Supplementary Material