Doxycycline and Benznidazole Reduce the Profile of Th1, Th2, and Th17 Chemokines and Chemokine Receptors in Cardiac Tissue from Chronic Trypanosoma cruzi-Infected Dogs

Figure 1

Expression of Th1-like chemokines in the cardiac tissue from dogs infected with Trypanosoma cruzi. Mongrel dogs were infected (black bars), or not (white bars), with Berenice-78 strain of T. cruzi and treated daily for 12 months with doxycycline (Dox), for 60 days with benznidazole (Bz), or in association with Dox + Bz (grey bars) and Th1-like chemokines CCL2, CCL3, CCL4, CCL5, CXCL9, and CXCL10 mRNA expression evaluated in left ventricle tissues from these animals. Data are representative of groups of 5 animals in which expression of chemokines was normalized to the constitutive beta-actin. in relation to the noninfected group; in relation to the infected group without treatment.

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