Doxycycline and Benznidazole Reduce the Profile of Th1, Th2, and Th17 Chemokines and Chemokine Receptors in Cardiac Tissue from Chronic Trypanosoma cruzi-Infected Dogs

Figure 6

Benznidazole and doxycycline reduce inflammation in the T. cruzi-infected left ventricle. Mongrel dogs infected with T. cruzi and treated with doxycycline (Dox), with benznidazole (Bz), or with the association of Dox + Bz had their heart extracted in the chronic phase to evaluate the inflammatory infiltration (H&E) in the left ventricle segment. The noninfected group was evaluated in parallel and sections were quantified in sections with 40x of magnification. Data are representative of the groups ( animals) and in relation to the noninfected group; in relation to the infected group without treatment; means difference () in relation to the Dox and Dox + Bz. LI: leukocytes infiltration.