Anti-Inflammatory Effects of TRAF-Interacting Protein in Rheumatoid Arthritis Fibroblast-Like Synoviocytes

<div>TRIP promoted K48-linked polyubiquitination of TAK1 in RA-FLS. Extracts of control RA-FLS and RA-FLS stably overexpressed TRIP or TRIPCA stimulated with TNF<i>α</i> (100 ng/mL) for 120 min were subjected to immunoprecipitation with anti-TAK1 and immunoblot analysis with antibody specific for K48-linked ubiquitin. Mg132, proteasome inhibitor. WCL, whole cell lysates.</div>

Mediators of Inflammation

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Figure 6

Figure 6: Anti-Inflammatory Effects of TRAF-Interacting Protein in Rheumatoid Arthritis Fibroblast-Like Synoviocytes 